a Record control number 000272099600005

a ISSN 0022-2151

a Original cataloging agency NEU GrandLibrary

a Language code of text/sound track or separate title eng

a Classification number WV100

b Item number .I58 2009

a Personal name Topak, M.

h Medium Electronic Document

a Title Intratympanic methylprednisolone injections for subjective tinnitus.

c Statement of responsibility, etc M.Topak, A. Sahin-Yilmaz, T. Ozdoganoglu, H. B. Yilmaz, M. Ozbay M. Kulekcı.

c Date of publication, distribution, etc 2009.

a Place of publication, distribution, etc Cambridge :

b Name of publisher, distributor, etc Cambridge Univ Press.,

a Summary, etc Objectives: This study aimed to determine whether intratympanically injected methylprednisolone is effective in treating subjective tinnitus refractory to medical treatment. Study design: Prospective, randomised, placebo-controlled, single-blinded study. Methods: Seventy adult patients with subjective tinnitus of cochlear origin were randomly assigned to receive intratympanic injection of either methylprednisolone or saline solution. The treatment protocol comprised three intratympanic injections, one per week for three weeks. Improvement in tinnitus severity was measured by a self-rated tinnitus loudness scale and by the tinnitus severity index, at baseline and two weeks after the last injection. Results: Data for 59 patients were available for analysis. There was no significant difference between the two treatment groups regarding age, sex, pure tone average, pretreatment tinnitus intensity, tinnitus laterality or tinnitus duration. There was a significant post-treatment improvement in self-rated tinnitus loudness scale results in both groups. No significant post-treatment changes in the tinnitus severity index individual and total scores were observed in either group. The most frequently encountered side effects were pain during injection, vertigo, a burning sensation around the ear and in the throat, and a bitter taste. A burning sensation and bitter taste were observed more often in the methylprednisolone group compared with the placebo group Conclusion: The results of this study indicate that intratympanic methylprednisolone has no benefit, compared with placebo, for the treatment of subjective tinnitus of cochlear origin refractory to medical treatment.

a Topical term or geographic name as entry element Near East University Article

a Topical term or geographic name as entry element Yakın Doğu Üniversitesi Makale

a Topical term or geographic name as entry element Otorhinolaryngology

a Topical term or geographic name as entry element Methylprednisolone

g Relationship information NOV 2009 , Vol 123 Issue 11, p1221-1225

t Title Journal Of Laryngology And Otology

x International Standard Serial Number 00222151

u Uniform Resource Identifier http://library.neu.edu.tr:2048/login?url=http://dx.doi.org/10.1017/S0022215109990685